Does Semax nasal spray work?

The human trial

The 2007 study, published in Russian, gave Semax 1% solution into the nose at 12 mg a day in two 10-day courses two weeks apart, and followed nerve and muscle function by electromyography and quality-of-life scales. The authors report that Semax did not influence the course of the disease or the clinical scores. The trial was open-label, with no placebo group.

For what is reported about Semax's adverse effects, see Semax side effects.

Does nasal Semax reach the brain?

A 2006 rat study tracked radiolabeled Semax given into the nose. Two minutes after dosing, 0.093% of the total radioactivity was found per gram of brain, 80% of it still intact Semax. The peptide broke down quickly, mostly to the fragment Pro-Gly-Pro. That shows rapid arrival in small amounts in rats; it has not been measured in people.

Where Semax stands with regulators

Semax nasal drops appear in Russia's state drug register, in two entries with 2025 certificate dates, according to the register search behind this page. DailyMed and Drugs@FDA hold no record of Semax in any form, and no FDA-approved Semax product exists.

What is sold

On October 7, 2026, Prof. Peptide counted Semax spray products at 17 of the 71 vendor catalogs it could read, and no Semax capsules or tablets. Spray is the format the research market sells it in; the human evidence for that format is the single trial above.