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Tirzepatide Half-Life Calculator

Tirzepatide is dosed once weekly. The figure used here is the one Prof. Peptide’s reference module carries, shown with its own citation — a half-life and an interval are all the model needs.

Last reviewed: September 21, 2026

A half-life and a schedule give a curve. Each dose decays on its own and the amounts add, which is what makes a compound accumulate or not.

~5 days (~120 hours)

Only compounds whose half-life Prof. Peptide can cite appear here. Half-life ~5 days, Tmax ~24h. Source: FDA prescribing information (Mounjaro).

Worked example

A half-life of 120 hours (the Mounjaro label’s approximately 5 days), dosed once weekly (168-hour interval):

Half-lives per interval168 h ÷ 120 h = 1.400
Accumulation ratio×1.610
Steady-state peak / trough1.6101 / 0.6101, per dose unit
Near steady state after600 hours (25 days, five half-lives)

Enter a dose, 168 for the interval, and any span into the calculator above and it returns the same ratios and a chart of the shape.

This is a single-compartment model. It assumes each dose is fully present the moment it’s given and decays at a constant rate. It ignores absorption, distribution into tissue, and every difference between one person and another. It is the arithmetic of a half-life and a schedule, not a prediction about a body.

FAQ

tirzepatide half life calculator accumulation
This page models tirzepatide's accumulation from the half-life Prof. Peptide's reference module carries — currently the Mounjaro label's approximately 5 days — and a dosing schedule you enter. Dosed once weekly, that's 1.4 half-lives per interval, giving a steady-state peak about 1.61 times a single dose.
Does tirzepatide accumulate more or less than semaglutide?
Less, at their respective once-weekly labelled intervals. Tirzepatide's shorter half-life (~5 days, against semaglutide's ~1 week) means more of each dose clears before the next lands — an accumulation ratio around 1.61 versus semaglutide's 2.0 for the same one-dose-per-week schedule. Compare both directly on the GLP-1 half-life calculator.
How long until tirzepatide reaches steady state?
About five half-lives — roughly 600 hours, or 25 days, at the Mounjaro label's approximately 5-day half-life.

To compare tirzepatide’s accumulation against semaglutide, retatrutide and cagrilintide, see the GLP-1 half-life calculator. For dosing and reconstitution arithmetic, see the tirzepatide reconstitution calculator.