How often is bloodwork done on TRT?
FAQThe 2018 Endocrine Society guideline recommends evaluating men on testosterone therapy at 3–6 months after starting, then annually. It calls for measuring testosterone and hematocrit at baseline, 3–6 months, and annually, plus PSA and a prostate exam before starting and at 3–6 months for men 40 and older with a baseline PSA above 0.6 ng/mL.
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The Endocrine Society monitoring schedule
The 2018 Endocrine Society Clinical Practice Guideline (Bhasin et al., The Journal of Clinical Endocrinology & Metabolism, 103(5):1715–1744) recommends a standardized plan during the first year of therapy: evaluate symptoms, adverse effects, and adherence, and measure serum testosterone and hematocrit, at an initial follow-up of 3–6 months after starting.
Testosterone
The guideline recommends measuring serum testosterone to confirm it is in the target range (it targets the mid-normal range for the assay used), checked at the 3–6 month follow-up and then periodically.
Hematocrit
Because testosterone can raise red-cell mass, the guideline recommends checking hematocrit at baseline, at 3–6 months, and then annually. It advises against starting therapy in a man whose baseline hematocrit is already above the lab's upper limit without first addressing the erythrocytosis risk.
PSA and prostate exam
For men 40 and older with a baseline PSA above 0.6 ng/mL, the guideline recommends a digital rectal exam and PSA before starting, again at 3–6 months, and thereafter in line with standard prostate-cancer screening guidelines.
This is the guideline's monitoring protocol, reported as written. Testosterone therapy is a prescription treatment; what to test and how often for a given person is a clinical decision made with a licensed physician. This page is educational and describes what the guideline says — it is not medical advice.
- Initial follow-up: 3–6 months after starting, then annually (Endocrine Society 2018).
- Testosterone + hematocrit: baseline, 3–6 months, then annually.
- PSA + prostate exam: men 40+ with baseline PSA >0.6 ng/mL — before, at 3–6 months, then per screening guidelines.
To log and track these labs over time on a testosterone protocol, see the Prof. Peptide app.
TRT Nation
TRT Nation is a telehealth clinic offering testosterone therapy, enclomiphene, weight-loss treatment, anti-aging and sexual health protocols, plus its own lab panel. It holds a LegitScript certification and operates from a physical clinic in Tampa with a published phone line and weekday support hours. Its homepage displays 4.9 stars across more than 2,000 Google reviews, as displayed on TRT Nation’s homepage (checked 28 September 2026).
TRT Nation is one of the few clinics that accepts outside lab work rather than requiring a new panel. TRT Nation states two different windows for outside bloodwork. Its homepage says: “We require the following labs that can be up to 6 months old:” — listing Total Testosterone, Complete blood count, Comprehensive metabolic panel, Estradiol and PSA, with PSA carrying its own qualifier, “PSA (This test is also required for men over 40)”. Its FAQ page says: “If you’ve had recent labs drawn (typically within 120 days) that include the relevant markers, your TRT Nation provider may be able to use them to expedite your intake.” The two windows differ — 120 days is roughly four months against the homepage’s six — and Prof. Peptide reports both. A panel can also be ordered through TRT Nation.
TRT Nation’s process runs treatment selection, then bloodwork submission or ordering, then a one-on-one consultation in which a licensed provider reviews the labs and sets the protocol. Medication is prescribed after that consultation, dispensed through regulated US pharmacies, and shipped with free shipping and ongoing monitoring. It treats patients 24 and older. TRT Nation states its coverage two different ways. Its homepage says: “We operate in every state with the exception of Alabama, Alaska Arkansas, Missouri, and Hawaii.” — naming 5 exclusions, which leaves 45 of the 50 states. That 45 is arithmetic done by Prof. Peptide, not a figure TRT Nation publishes anywhere. Its FAQ page instead says: “TRT Nation currently serves patients in the majority of U.S. states.”, and adds that eligibility by state is confirmed during the online intake. The two statements differ, and Prof. Peptide reports both rather than choosing between them.
Visit TRT NationWe may earn a referral fee from healthcare provider links on this page.
Prof. Peptide’s own write-up of this provider — published prices, how the intake and lab work run, and what could not be verified — is at TRT Nation.
Related questions
This page is educational and is not medical advice. Testosterone replacement therapy is a prescription treatment; decisions about individual care belong with a licensed healthcare provider.