Can testosterone be injected subcutaneously?
FAQYes. Xyosted, an FDA-approved testosterone enanthate auto-injector, is labeled for once-weekly subcutaneous injection in the abdomen (75 mg, titratable 50–100 mg). The classic testosterone labels — Depo-Testosterone and Delatestryl — are intramuscular only. A 2018 pharmacokinetic study found subcutaneous testosterone delivered exposure comparable to intramuscular injection.
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Yes — there is an FDA-approved subcutaneous product
Xyosted (testosterone enanthate) is FDA-approved for testosterone replacement in adult men by once-weekly subcutaneous injection in the abdominal region. Its labeled starting dose is 75 mg once a week, adjustable to a range of 50 to 100 mg. That approval is the direct answer: testosterone can be injected subcutaneously, and there is a product specifically labeled for that route.
The classic labels are intramuscular only
The older testosterone ester labels are written for intramuscular use. Depo-Testosterone (testosterone cypionate) states intramuscular use only, and Delatestryl (testosterone enanthate) states “for intramuscular use only,” injected deep in the gluteal muscle. The subcutaneous route is specific to products such as Xyosted that are labeled for it.
What a pharmacokinetic comparison found
A 2018 pilot pharmacokinetic study (Wilson, Kiang, and Ensom, American Journal of Health-System Pharmacy, 75(6):351–358) compared subcutaneous and intramuscular testosterone injection in people on stable therapy. It reported that total testosterone exposure was comparable between the two routes (mean AUC 1.7 versus 1.9 nmol·days/L/mg, p > 0.05) and that the subcutaneous route was more tolerable. This is that study's finding, reported as such.
What this means
The named sources support that subcutaneous testosterone injection is an established, FDA-approved route (Xyosted) and that a published comparison found it delivered testosterone exposure comparable to intramuscular injection. Testosterone is a prescription medication and a controlled substance; route and dose are clinical decisions made with a licensed physician. This page is educational and describes what the documents say — it is not medical advice.
- Xyosted is FDA-approved for once-weekly subcutaneous testosterone (75 mg, 50–100 mg range).
- Depo-Testosterone and Delatestryl are labeled intramuscular only.
- A 2018 study (Am J Health-Syst Pharm 75(6):351) found SC exposure comparable to IM (AUC 1.7 vs 1.9, p > 0.05).
For estimated testosterone level curves modelled from published pharmacokinetic data across weekly and every-two-week schedules, see the Prof. Peptide app.
TRT Nation
TRT Nation is a telehealth clinic offering testosterone therapy, enclomiphene, weight-loss treatment, anti-aging and sexual health protocols, plus its own lab panel. It holds a LegitScript certification and operates from a physical clinic in Tampa with a published phone line and weekday support hours. Its homepage displays 4.9 stars across more than 2,000 Google reviews, as displayed on TRT Nation’s homepage (checked 28 September 2026).
TRT Nation is one of the few clinics that accepts outside lab work rather than requiring a new panel. TRT Nation states two different windows for outside bloodwork. Its homepage says: “We require the following labs that can be up to 6 months old:” — listing Total Testosterone, Complete blood count, Comprehensive metabolic panel, Estradiol and PSA, with PSA carrying its own qualifier, “PSA (This test is also required for men over 40)”. Its FAQ page says: “If you’ve had recent labs drawn (typically within 120 days) that include the relevant markers, your TRT Nation provider may be able to use them to expedite your intake.” The two windows differ — 120 days is roughly four months against the homepage’s six — and Prof. Peptide reports both. A panel can also be ordered through TRT Nation.
TRT Nation’s process runs treatment selection, then bloodwork submission or ordering, then a one-on-one consultation in which a licensed provider reviews the labs and sets the protocol. Medication is prescribed after that consultation, dispensed through regulated US pharmacies, and shipped with free shipping and ongoing monitoring. It treats patients 24 and older. TRT Nation states its coverage two different ways. Its homepage says: “We operate in every state with the exception of Alabama, Alaska Arkansas, Missouri, and Hawaii.” — naming 5 exclusions, which leaves 45 of the 50 states. That 45 is arithmetic done by Prof. Peptide, not a figure TRT Nation publishes anywhere. Its FAQ page instead says: “TRT Nation currently serves patients in the majority of U.S. states.”, and adds that eligibility by state is confirmed during the online intake. The two statements differ, and Prof. Peptide reports both rather than choosing between them.
Visit TRT NationWe may earn a referral fee from healthcare provider links on this page.
Prof. Peptide’s own write-up of this provider — published prices, how the intake and lab work run, and what could not be verified — is at TRT Nation.
Related questions
This page is educational and is not medical advice. Testosterone replacement therapy is a prescription treatment; decisions about individual care belong with a licensed healthcare provider.