How often is testosterone enanthate injected?
FAQTwo FDA labels for testosterone enanthate give different schedules. The classic intramuscular label (Delatestryl lineage) states 50–400 mg every two to four weeks. Xyosted, an FDA-approved weekly subcutaneous auto-injector, states 75 mg once a week, titratable 50–100 mg. The 2018 Endocrine Society guideline describes 75–100 mg weekly or 150–200 mg every two weeks.
What the intramuscular label states
The FDA prescribing information for intramuscular testosterone enanthate (the Delatestryl lineage, a Schedule III controlled substance) gives the replacement dosage as 50 to 400 mg every two to four weeks, for intramuscular use only, injected deeply into the gluteal muscle. The label attributes the multi-week interval to slow absorption of the ester from its oil depot rather than to a long half-life of testosterone itself — it states testosterone's half-life as 10 to 100 minutes.
What the Xyosted label states (weekly subcutaneous)
Xyosted is an FDA-approved testosterone enanthate auto-injector for once-weekly subcutaneous injection in the abdomen. Its labeled starting dose is 75 mg once a week, adjustable in 25 mg steps to a range of 50 to 100 mg weekly based on testosterone trough levels. This is a different route and a shorter interval than the classic intramuscular label — reported here as the Xyosted label states it.
What the Endocrine Society guideline describes
The 2018 Endocrine Society Clinical Practice Guideline (Bhasin et al., The Journal of Clinical Endocrinology & Metabolism, 2018) lists, as typical starting doses for intramuscular testosterone enanthate or cypionate, 150–200 mg every two weeks or 75–100 mg weekly.
Where the enanthate schedules differ
Across the named sources the intervals differ: the classic intramuscular label, 50–400 mg every two to four weeks; Xyosted, 75 mg (50–100 mg) subcutaneously once weekly; the Endocrine Society guideline, 75–100 mg weekly or 150–200 mg every two weeks. Each is reported as its source states it. Testosterone enanthate is a prescription medication and a controlled substance; which schedule applies to a given person is a clinical decision made with a licensed physician. This page is educational and describes what the documents say — it is not medical advice.
- Classic IM label (Delatestryl lineage): 50–400 mg intramuscularly every two to four weeks.
- Xyosted (FDA-approved): 75 mg subcutaneously once weekly, titratable 50–100 mg.
- 2018 Endocrine Society guideline: 75–100 mg weekly or 150–200 mg every two weeks.
For estimated testosterone level curves modelled from published pharmacokinetic data across weekly, every-two-week, and titration schedules, see the Prof. Peptide app.
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Research use only. Not medical advice.