How often is testosterone enanthate injected?
FAQTwo FDA labels for testosterone enanthate give different schedules. The classic intramuscular label (Delatestryl lineage) states 50–400 mg every two to four weeks. Xyosted, an FDA-approved weekly subcutaneous auto-injector, states 75 mg once a week, titratable 50–100 mg. The 2018 Endocrine Society guideline describes 75–100 mg weekly or 150–200 mg every two weeks.
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What the intramuscular label states
The FDA prescribing information for intramuscular testosterone enanthate (the Delatestryl lineage, a Schedule III controlled substance) gives the replacement dosage as 50 to 400 mg every two to four weeks, for intramuscular use only, injected deeply into the gluteal muscle. The label attributes the multi-week interval to slow absorption of the ester from its oil depot rather than to a long half-life of testosterone itself — it states testosterone's half-life as 10 to 100 minutes.
What the Xyosted label states (weekly subcutaneous)
Xyosted is an FDA-approved testosterone enanthate auto-injector for once-weekly subcutaneous injection in the abdomen. Its labeled starting dose is 75 mg once a week, adjustable in 25 mg steps to a range of 50 to 100 mg weekly based on testosterone trough levels. This is a different route and a shorter interval than the classic intramuscular label — reported here as the Xyosted label states it.
What the Endocrine Society guideline describes
The 2018 Endocrine Society Clinical Practice Guideline (Bhasin et al., The Journal of Clinical Endocrinology & Metabolism, 2018) lists, as typical starting doses for intramuscular testosterone enanthate or cypionate, 150–200 mg every two weeks or 75–100 mg weekly.
Where the enanthate schedules differ
Across the named sources the intervals differ: the classic intramuscular label, 50–400 mg every two to four weeks; Xyosted, 75 mg (50–100 mg) subcutaneously once weekly; the Endocrine Society guideline, 75–100 mg weekly or 150–200 mg every two weeks. Each is reported as its source states it. Testosterone enanthate is a prescription medication and a controlled substance; which schedule applies to a given person is a clinical decision made with a licensed physician. This page is educational and describes what the documents say — it is not medical advice.
- Classic IM label (Delatestryl lineage): 50–400 mg intramuscularly every two to four weeks.
- Xyosted (FDA-approved): 75 mg subcutaneously once weekly, titratable 50–100 mg.
- 2018 Endocrine Society guideline: 75–100 mg weekly or 150–200 mg every two weeks.
For estimated testosterone level curves modelled from published pharmacokinetic data across weekly, every-two-week, and titration schedules, see the Prof. Peptide app.
TRT Nation
TRT Nation is a telehealth clinic offering testosterone therapy, enclomiphene, weight-loss treatment, anti-aging and sexual health protocols, plus its own lab panel. It holds a LegitScript certification and operates from a physical clinic in Tampa with a published phone line and weekday support hours. Its homepage displays 4.9 stars across more than 2,000 Google reviews, as displayed on TRT Nation’s homepage (checked 28 September 2026).
TRT Nation is one of the few clinics that accepts outside lab work rather than requiring a new panel. TRT Nation states two different windows for outside bloodwork. Its homepage says: “We require the following labs that can be up to 6 months old:” — listing Total Testosterone, Complete blood count, Comprehensive metabolic panel, Estradiol and PSA, with PSA carrying its own qualifier, “PSA (This test is also required for men over 40)”. Its FAQ page says: “If you’ve had recent labs drawn (typically within 120 days) that include the relevant markers, your TRT Nation provider may be able to use them to expedite your intake.” The two windows differ — 120 days is roughly four months against the homepage’s six — and Prof. Peptide reports both. A panel can also be ordered through TRT Nation.
TRT Nation’s process runs treatment selection, then bloodwork submission or ordering, then a one-on-one consultation in which a licensed provider reviews the labs and sets the protocol. Medication is prescribed after that consultation, dispensed through regulated US pharmacies, and shipped with free shipping and ongoing monitoring. It treats patients 24 and older. TRT Nation states its coverage two different ways. Its homepage says: “We operate in every state with the exception of Alabama, Alaska Arkansas, Missouri, and Hawaii.” — naming 5 exclusions, which leaves 45 of the 50 states. That 45 is arithmetic done by Prof. Peptide, not a figure TRT Nation publishes anywhere. Its FAQ page instead says: “TRT Nation currently serves patients in the majority of U.S. states.”, and adds that eligibility by state is confirmed during the online intake. The two statements differ, and Prof. Peptide reports both rather than choosing between them.
Visit TRT NationWe may earn a referral fee from healthcare provider links on this page.
Prof. Peptide’s own write-up of this provider — published prices, how the intake and lab work run, and what could not be verified — is at TRT Nation.
Related questions
This page is educational and is not medical advice. Testosterone replacement therapy is a prescription treatment; decisions about individual care belong with a licensed healthcare provider.